Ellagic acid exhibits multi-target neuroprotective effects, including inhibition of Aβ oligomerization, regulation of Tau protein hyperphosphorylation, enhancement of synaptic plasticity, and maintenance of mitochondrial homeostasis (Javaid et al., 2021; Zhu et al., 2022; Jha et al., 2024), Calycosin alleviates oxidative stress and inflammation in the hippocampus of AD model mice by activating the protein kinase C pathway, thereby improving cognitive function (Song et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.