Figure 2B illustrates the transcriptional profiles of these eight genes in the TCGA dataset, revealing expression patterns that were consistent with those observed in Figure 2A. In ccRCC tissue, compared to normal kidney tissue, EPAS1, BID, AURKA, EZH2, and PLA2G6 exhibited significantly elevated expression levels. Conversely, the expression of SCP2, ALDH3A2, and PRKAA2 significantly reduced in ccRCC tissue. Supplementary Figure 3 illustrates the transcriptional data for various predictive ferroptosis-related genes from the GSE53757 dataset. This evidence concerns the gene SCP2 and nonpapillary renal cell carcinoma.