Among these, VHL displayed the highest mutation rate (60.6%), followed by PBRM1 (50.2%), TTN (20.8%), SETD2 (15.2%), BAP1 (12.3%), etc. The prevalence of mutations in these genes showed their potential significance in the pathogenesis of ccRCC. Here, SETD2 is linked to nonpapillary renal cell carcinoma.