The search strategy integrated controlled vocabulary and free-text keywords with Boolean operators, focusing on four conceptual clusters: (1) UC-related terms (“ulcerative colitis” OR “UC”), (2) pyroptosis (“pyroptosis” OR “gasdermin D” OR “caspase-1”), (3) NLRP3 (“NLRP3” OR “NOD-like receptor protein 3”), and (4) therapeutic interventions (“natural products” OR “traditional Chinese medicine” OR “TCM” OR “herb”). Here, NLRP3 is linked to ulcerative colitis.