Immunofluorescent staining revealed increased infiltration and exhaustion of CD8+ T cells in the tumor tissues of mice in the sh-LOX, sh-LOXL1, sh-LOXL2, sh-LOXL3, and sh-LOXL4 groups, compared to the sh-NC group (Figure 10G). The gene discussed is LOXL4; the disease is neoplasm.