KIT mutations are associated with enhanced proliferation of MCs and are frequently detectable in AML1::ETO+ AML, AML that occurs concomitantly often harbors the same KIT mutations to those found in neoplastic MCs, existing evidence suggests that leukemic blasts and MCs derive from a common malignant progenitor (4, 5). Here, RUNX1T1 is linked to acute myeloid leukemia.