It is worth noting that macrophages within the TME are divided into two classes: macrophages with anti-tumor activities, called M1 phenotypes, which are identified by the expression/secretion of CD64, CD86, IL-12, ROS, and inducible nitric oxide synthase (iNOS), and macrophages with pro-tumorigenic activities, called M2 phenotypes, which are characterized by the expression/secretion of CD163, CD206, arginase-1 (ARG-1), and TGF-β (89–91). The gene discussed is NOS2; the disease is neoplasm.