In particular, cell activation proteins like HLA-DRB, HLA-DRA, and CD63 (lysosome-associated membrane proteins-3, LAMP-3) were among the most over-expressed proteins (36.05, 30.99, and 22.45-fold higher in neutrophils from RA-SF versus autologous blood, Supplementary Table S2). This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.