Male individuals exhibited different upregulated genes, such as CD180, GAPT, and TLR7; meanwhile, a downregulation of KLHL21, MYLIP, PDE4A, and ZNFX1. A sex-dependent expression of genes was also detected among the systemic disease-associated uveitis patients, with the genes CA1, CCR7, CD3E, and LCK being differentially regulated in male and female patients compared with healthy individuals of the same sex. Here, CCR7 is linked to uveitis.