FN1 and neoplasm: PDAC has evolved into a unique tumor microenvironment (TME) that includes cancer-associated fibroblasts (CAFs), pancreatic stellate cells (PSCs), regulatory T-cells, tumor-associated macrophages (TAMs), and a large amount of extracellular matrix (ECM) rich in hyaluronic acid, fibronectin, chemokines, cytokines, and extracellular proteases.15 On the one hand, PDAC is genetically diverse, with a low mutational load and few neoantigens, resulting in low PDAC antigenicity.