Rotavirus infection activates the PI3K/AKT/mTORC1 signaling pathway to inhibit autophagy, promoting viral self-replication (Yin et al., 2018), and the influenza A virus protein NS1 phosphorylates AKT to inhibit REDD1 activity and activate mTORC1 promote viral replication in the later stage of infection (Kuss-Duerkop et al., 2017). Here, AKT1 is linked to Rotavirus infection.