PNPLA3 and metabolic dysfunction-associated steatotic liver disease: NAFLD increases oxidative stress, inflammatory and fibrotic markers (can be electrochemically active) such as TIMP1, PNPLA3, TNF-α, NF-κB, and IL-6 in the liver tissue/plasma (as discussed in Figure 10), neurodegeneration, gut disruption, and histological damage in the liver [39], kidney [40], and spleen [41].