In a study utilizing a glaucoma mouse model to investigate the role of Cx43 in TM functional regeneration, knockdown of Cx43 expression was shown to attenuate the transplantation of induced pluripotent stem cell (iPSC)-derived TM cells, hinder TM function recovery, suppress endogenous TM cell division, and prevent the restoration of disrupted IOP homeostasis in glaucoma (Sui et al., 2021). The gene discussed is GJA1; the disease is glaucoma.