The nomogram we constructed using the above independent risk factors exhibited good ability for predicting RFS in early-stage IBC patients with HR<sup>+</sup>.<h4>Conclusion</h4>Chemotherapy, TOP2A, HER2, and Ki67 expression were independent predictors of RFS in early-stage IBC patients with HR<sup>+</sup>. Here, TOP2A is linked to inflammatory breast carcinoma.