However, mechanistic insights from murine tumor models with TLSs suggest functional parallels: T and B cells expressing lipoteichoic acid (LTA) have been identified as potential LTi-like cells, while podoplanin-positive (PDPN+) fibroblasts expressing lymphotoxin-beta receptor (LTBR) may act as LTo-like cells (128). This evidence concerns the gene PDPN and neoplasm.