In sporadic Burkitt lymphoma, erroneous AID-mediated class-switch recombination (CSR) drives immunoglobulin locus (Ig)-MYC translocations, while diffuse large B-cell lymphomas (DLBCLs) commonly harbor Ig-BCL6 translocations through similar mechanisms. The gene discussed is AICDA; the disease is diffuse large B-cell lymphoma.