ACAT2 and neoplasm: This action reduces the infiltration of CD206+ (M2) macrophages into the tumor and down-regulates the expression of the cholesterol transporter genes ABCA1, ABCG1 and ATP-binding cassette sub-family A member 6 (ABCA6), as well as the cholesterol synthesis-related genes mitochondrial acetyl-CoA acetyltransferase (ACAT1) and cytosolic acetyl-CoA acetyltransferase (ACAT2) in these cells (94).