In addition, Huang et al. showed that S100A8/A9 were located in Ly6G-positive neutrophils in AKI mice and that the expression of CXCR2 and S100A8/A9 was strongly correlated in the transcriptome of immune cells in AKI (Huang et al., 2023). Here, IGKV1D-22 is linked to acute kidney injury.