In several inflammation-related diseases, such as myocardial infarction, acute lung injury, acute kidney injury, and cancer, S100A8/A9 were reported to be valuable biomarkers (Wang et al., 2023; Li et al., 2019; Gong et al., 2024; Chen et al., 2024). Here, IGKV1D-22 is linked to myocardial infarction.