As shown in Figure 8, compared with the RA model group, 17a-estradiol, 5-methylcytidine, arginine, aspartic acid, cer(d18:0/18:0), citric acid, isocitric acid, L-glutamate, LysoPC(15:0), LysoPC(18:0), LysoPC(18:1), phytanic acid, pyruvic acid, LysoPE(0:0/20:0), and vitamin K2 levels were significantly upregulated in the ICA-treated group; in contrast, arachidonic acid, glutamine, glycochenodeoxycholate, L-aspartyl-4-phosphate, succinic acid, PGE2, taurochenodeoxycholate, and taurocholic acid levels were significantly downregulated in the ICA-treated group. The gene discussed is CBLN1; the disease is rheumatoid arthritis.