The RA model animals evidently showed morbid states leading to greater concentrations of LDH, GST, AST, ALT, MMP-3, IL-6, TNF-α in the blood, and MDA in the tissues along with decreased concentrations of CAT in the blood as well as GSH-PX and SOD in the tissues compared to the control group. This evidence concerns the gene TNF and rheumatoid arthritis.