In addition, a mouse model of whole-body β2-AR knockout (KO) in the SKH-1 background and the wild-type (WT) SKH-1 littermate control mice were used in short-term and long-term UV exposure protocols to elucidate the role of β2-AR in UV-induced immunosuppression and skin cancer development. The gene discussed is ADRB2; the disease is skin neoplasm.