ADRB2 and neoplasm: It has been shown that the immunosuppressive effects of catecholamines in tumor microenvironment are mainly mediated through the β2-AR (Mohammadpour et al, 2019; Qiao et al, 2019), and β2-AR is involved in the induction of regulatory T cells (Tregs) (Guereschi et al, 2013) and in the suppression of effector T cells (Bucsek et al, 2017).