Therefore, the primary objective of this study is to explore the potential mediating effects and underlying biological mechanisms of the inflammatory response, measured by traditional and novel inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP), white blood cell (WBC), systemic immune inflammation index (SII) and system inflammation response index (SIRI), and the oxidative stress response, represented by oxidative markers including gamma-glutamyl transpeptidase (GGT), albumin, ferritin, and total bilirubin, in the association between sleep disorder and infertility risk. Here, CRP is linked to sleep disorder.