Through the utilization of a fully adjusted regression model, our research revealed a significant positive relationship between sleep disorder and hs-CRP (β: 0.94, 95%CI: 0.00–1.87), SII (β: 54.29, 95%CI: 21.04–87.53), SIRI (β: 0.12, 95%CI: 0.02–0.22), and GGT (β: 4.95, 95%CI: 1.21–8.70) levels. The gene discussed is CRP; the disease is sleep disorder.