DNASE1 and anti-neutrophil cytoplasmic antibody-associated vasculitis: Propylthiouracil (PTU) is able to inhibit the activity of DNase I. As a result, this inhibition gives rise to the accumulation of NETs in the body, which further impairs vascular endothelial cells, eventually leading to the development of ANCA - associated vasculitis (AAV) (13).