Once neutrophils are sensitized and the antigens translocate to the cell membrane, ANCA can bind to neutrophil antigens, including protease - 3 (PR3), myeloperoxidase (MPO), and cathepsin G, which leads to neutrophil degranulation (10).In the present case, granulocyte colony - stimulating factor was administered to elevate the white blood cell count, meropenem, piperacillin sodium, and sulbactam sodium were utilized for anti - infection purposes, and hormones were applied for a short - term. The gene discussed is CTSG; the disease is infection.