EPCAM and neoplasm: The immunomodulatory functions of OMVs derived from probiotics, such as E. coli Nissle and Akk, are increasingly recognized for their roles in triggering innate immune signaling, inducing trained immunity, and activating T and B lymphocytes.[22] In our study, we specifically designed the hybrid OMV incorporating a tumor‐targeting peptide designed for treating CD326‐overexpressed malignancies.