CD8A and neoplasm: Additionally, tumor immune markers for infiltrating T cells (e.g., CD3, CD4, and CD8) were detected at obviously lower levels in the high‐Cu zones than in low‐Cu zones (Figure 2E), suggesting an immune‐desert phenotype (characterized by a paucity of T cells in either the parenchyma or the stroma of the tumor[16]) in the high‐Cu zones.