To assess the specific interaction of TM@CD326hOMV with tumor cells in vitro, 4T1 cells (CD326+) and HeLa cells (CD326−) were incubated with fluorescein isothiocyanate (FITC)‐labeled TM@CD326hOMV or TM@hOMV at 4 °C. This evidence concerns the gene EPCAM and neoplasm.