To further analyze the tumor subpopulations and immune microenvironment reshaped by TM@CD326hOMV, IMC was performed using a biomarker panel including immune‐related proteins (CD3, CD4, and CD8), Cu‐associated proteins (COX IV and CCS), and tumor metastasis/migration biomarkers (LOX, vimentin, and collagen I) (Figure 5E–H). This evidence concerns the gene CD8A and neoplasm.