Dysregulation of the Notch signaling pathway is closely related to tumor proliferation, invasion, and metastasis.[40] The Notch signaling pathway is involved in the maintenance of the stem cell‐like characteristics of cancer cells, thereby enhancing cancer invasiveness.[41] In this study, we demonstrated that elevated SNORA74A binds DCAF13 to prevent K48 linked ubiquitination of E2F2, maintaining the E2F2 stability. This evidence concerns the gene E2F2 and neoplasm.