TRIM48 and hepatocellular carcinoma: Considering PRMT1 overexpression in various human malignancies, understanding its regulatory mechanisms is crucial.[30] PRMT1 undergoes proteasome‐mediated degradation; for instance, TRIM48 facilitates its ubiquitination, promoting oxidative stress‐induced cell death, while FBXO7‐mediated degradation suppresses serine synthesis and inhibits HCC growth.[11, 22, 31] Additionally, non‐coding RNAs such as miR‐503 and LINC01431 modulate PRMT1 expression, yet its transcriptional regulation in tumors remains largely unexplored.