PTBP3 and liver cancer: Overexpression of miR‐297 inhibits the proliferation, migration, and invasion of liver cancer cells by downregulating PTBP3 expression, subsequently suppressing the PI3K/AKT signaling pathway.[43] Given that splicing often occurs concurrently with transcription, the elongation rate of the key enzyme RNA polymerase II (RNA pol II) can influence the rate of alternative splicing.