Overexpression of miR‐297 inhibits the proliferation, migration, and invasion of liver cancer cells by downregulating PTBP3 expression, subsequently suppressing the PI3K/AKT signaling pathway.[43] Given that splicing often occurs concurrently with transcription, the elongation rate of the key enzyme RNA polymerase II (RNA pol II) can influence the rate of alternative splicing. The gene discussed is AKT1; the disease is liver cancer.