Over the past decade, numerous studies have identified genetic variants in TMEM106B as important modifiers of disease risk in various neurodegenerative disorders, including Frontotemporal lobar degeneration (FTLD), Alzheimer’s disease (AD), Parkinson’s disease, hypomyelinating leukodystrophy, chronic traumatic encephalopathy (CTE), limbic-predominant age-related TDP- 43 encephalopathy (LATE), and hippocampal sclerosis in aging [1–11]. Here, TMEM106B is linked to Alzheimer disease.