Indeed, a transgenic αsyn/amyloid/tau pathology mouse line (DLB-AD), established by crossing the 3xTg-AD [161] amyloid/tau line with the M83-h [216] mutant A53T αsyn line, demonstrated that αsyn pathology is capable of promoting Aβ and tau accumulation [3]. The gene discussed is MAPT; the disease is Alzheimer disease.