MAPT and dementia: About 25% of dementia cases are neuropathologically diagnosed as LBD due to the presence of α-synuclein (αsyn) aggregates in cytoplasmic structures known as Lewy bodies (LB) and Lewy neurites (LN), accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFT), and of β-amyloid (Aβ) into amyloid plaques [2].