A recent Chinese cohort study with 105 cases of chronic hepatitis, 116 of liver cirrhosis, and 101 of HCC showed that serum OPN analyses gave a better AUROC of 0.851 (79.2% sensitivity and 79.6% specificity) compared with AFP (AUROC of 0.683) or DKK1 (AUROC of 0.639) (Zhu et al. 2020) (Table 1). This evidence concerns the gene SPP1 and hepatocellular carcinoma.