High mobility group box 2 (HMGB2), closely related to HMGB1 is overexpressed in HCC cells (Kwon et al. 2010; Lu et al. 2023), via activating signaling pathways such as ERK, PI3K/AKT, and Wnt/β-catenin. This evidence concerns the gene AKT1 and hepatocellular carcinoma.