MLLT3 and acute myeloid leukemia: We then examined whether mAb2 can also target csNPM1 in primary murine AML models by performing live staining followed by flow cytometry analysis), finding mAb2 can bind these cells as well driven by Npm1A/+/Flt3ITD/+, MLL-AF9/Flt3ITD/+, MLL-ENL/Flt3ITD/+, and Npm1c/NrasG12D/+ (Extended Data Figure 3C).Overall, the broadly observed and high levels of mAb2 binding on AML bone marrow suggests that csNPM1 could serve as a genotype-agnostic marker of AML.