The broad expression of csNPM1 on models with or without NPM1c and the higher expression on models with NPM1c (i.e. OCI-AML3 and Npm1c/Flt3ITD/+ murine AML) raises the question of whether both the wild-type and mutant forms of NPM1 can be presented on the cell surface, especially considering NPM1c can form heterodimers with wild-type NPM135. The gene discussed is RUNX2; the disease is acute myeloid leukemia.