In addition to the lower magnitude SARS-CoV-2-specific antibody responses observed in PLWH recovered from symptomatic outpatient COVID-19, the correlation networks indicated a significantly less-coordinated immune response against SARS-CoV-2 in PLWH: while antibody binding, functional antibody responses, B cell and CD4+ T cell magnitudes all closely correlated in PWOH, there were fewer nodes within clusters of immune markers in PLWH, with both IgA and IgG3 binding antibodies no longer represented in the main cluster. Here, IGHG3 is linked to COVID-19.