Among participants recovered from symptomatic outpatient or hospitalized COVID-19, most correlations between SARS-CoV-2 and endemic CoV antibody binding became weak or negative in PLWH, with the exception of the correlation between SARS-CoV-2-specific IgG3 antibodies and endemic CoV IgG3 antibodies, which became stronger in participants recovered from hospitalization (Supplementary Fig. 5: bottom right panel). The gene discussed is IGHG3; the disease is COVID-19.