IGHG3 and COVID-19: The correlation network for PWOH who recovered from symptomatic outpatient COVID-19 included a large, central cluster encompassing SARS-CoV-2-specific binding antibody responses (IgA, IgG1 and IgG3; purples) and multiple functional antibody measurements (e.g., neutralization, ACE2 blocking and ADCC; blue and green) connected to separate clusters of SARS-CoV-2-specific CD4 T cells (red) by Spike-specific CD4 T cells (marker 47), and IgG+ B cells (green, yellow) (Fig. 4, left panel).