Of note, Spearman’s rank correlation coefficients for SARS-CoV-2 RBD and Spike-specific IgG3 antibodies (markers 10, 13, and 14) with IgG3 antibodies binding to all endemic RBDs (markers 23–26) in PWOH recovered from asymptomatic infection were 0.53–0.70, with all p values < 0.001 (Supplementary Fig. 5: left panels). This evidence concerns the gene IGHG3 and infection.