KEGG analysis revealed two processes, Huntington’s disease and Amyotrophic lateral sclerosis, whereas the REACTOM database revealed one item: EGFR downregulation, with three genes, protein-tyrosine phosphatase (PTP)-PEST (PTPN12), epidermal growth factor receptor (EGFR), and epsin 1 (EPN1) (Supplementary Table S4). The gene discussed is EPN1; the disease is juvenile Huntington disease.