CALCA and pancreas disorder: To determine whether this was correlated with a difference in pancreatic disease burden, we evaluated the pancreata from a separate cohort of mice and found that, compared with pancreata from their KC Pikfyve+/+ littermates, pancreata from KC Pikfyvef/+ and KC Pikfyvef/f mice weighed less and were closer in weight to the pancreata of wild-type mice at 27 weeks of age (Extended Data Fig. 2c,d).