Pharmacological inhibition of PIKfyve with apilimod or ESK981 also showed similar effects in 7940B and Panc 04.03 (human PDAC) cells (Extended Data Fig. 4c), as well as in vivo in UM-2 pCDX tumours (Extended Data Figs. 3r–t, 4d). This evidence concerns the gene PIKFYVE and neoplasm.