PIKFYVE and keratoconus: We then sought to evaluate the effect of Pikfyve loss on PDAC development by crossing Pikfyve+/+, Pikfyvef/+ and Pikfyvef/f with the KC model (Ptf1a-Cre;LSL-KrasG12D/+) to assess pancreatic tumorigenesis (Fig. 1d and Extended Data Fig. 2a,b).