ANGPT1 and COVID-19: Reindl-Schwaighofer et al.18 found that circulating ACE2 levels in patients with severe COVID-19 increased sevenfold from early to late following admission, and that this increase was accompanied by increased ANG1–7 levels and ANG1–7/ANGII ratio, suggesting a shift towards the alternative RAS and increased organ protection later in the disease course.