MAPT and Alzheimer disease: We administered R8-LMNPs by tail vein injection (10 mg/kg) immediately following intranasal administration of mannitol to 5.5-month-old, male, heterozygous 5xFAD mice (n = 3) and 5-month-old, male, heterozygous PS19 mice seeded with AD brain-extracted tau fibrils in the left and right hippocampus (n = 4).