In vagal ganglia from DSS-colitis mice, our transcriptomic data point to a downregulation of Ramp1 and Ramp2 alongside an upregulation of Syt7, a calcium sensor for neurotransmitter release57, and the sodium channel Scn10a (Nav1.8) which plays an important role in membrane excitability (Fig. 5)58. Here, SYT7 is linked to colitis.