We then integrated the results obtained in vitro and with the murine prostate cancer model and identified two proteins consistently altered upon PGC1α perturbation in PCa, ATPase Na + /K+ Transporting Subunit Beta 1 (ATP1B1) and spermidine synthase (SRM) (Fig. 3C and Supplementary Fig. 3B). Here, SRM is linked to posterior cortical atrophy.