Conditioned media experiments using prostate cancer cells with inducible expression of PGC1α and CRISPR-CAS9-induced deletion of ERRα ([11]; Supplementary Fig. 2A, B) showed that loss of ERRα in producer cells prevented the paracrine action of PGC1α in recipient cells (Fig. 2A). This evidence concerns the gene PPARGC1A and Familial prostate cancer.