Intriguingly, this non-cell autonomous suppressive effect of PGC1α-expressing cells was progressively lost at later time points of tumor growth (Fig. 4D and Supplementary Fig. 4E), most probably due to the loss of the paracrine suppressive pressure from PGC1α-expressing cells, as the presence of these cells is diminished over time. Here, PPARGC1A is linked to neoplasm.