Moreover, in line with the role of ERRα in the transcriptional effects of PGC1α [1, 11], the analysis of PCa patient transcriptomes revealed a consistent inverse correlation between SRM mRNA levels and the expression of a PCa specific PGC1α-ERRα transcriptional signature [1] (Supplementary Fig. 5A, B). This evidence concerns the gene PPARGC1A and posterior cortical atrophy.