This data along with other PD-related truncations (e.g. 5–140, 39–140, 65–140, 68–140, Ac1–103, and Ac1–122) being derived from the soluble state by cathepsin activity (Supplementary Fig. 1), reiterates the involvement of lysosomal function in generating other amyloidogenic α-syn variants and could bear pathological consequences. The gene discussed is CTSS; the disease is Parkinson disease.