NR1H4 and fatty liver disease: An intervention trial suggests that the colonization of Akkermansia muciniphila increases L-aspartate levels, which ameliorates lipid accumulation and oxidation stress in the metabolic dysfunction-associated fatty liver by activating the LKB1-AMPK axis.66 Additionally, Akkermansia muciniphila alleviates hepatic steatosis and inflammation in mice on a high-fat diet by regulating the gut FXR-FGF15 signaling axis.67 However, whether Akkermansia muciniphila is a key bacterium in regulating hepatic lipid synthesis under a KD requires further investigation.