IDH1 and neoplasm: Considering that discriminatory capacity might be biased by different confounders clinical and molecular tumour features (Verhaak subtype, IDH1 mutations, G-CIMP status, MGMT methylation, age, gender), all these different confounders factors were evaluated individually in the TGCA external cohort (i.e., the most clinically/molecularly complete external cohort) and compared with the previous univariate analysis showed above (Supplementary Table S1).