In this regard, we aimed (i) to analyse circulating concentrations of IL-36γ as well as IL36G and IL36R gene expression levels in VAT biopsies from patients with and without colorectal cancer subclassified as normal-weight or with obesity, (ii) to examine the role of inflammation-related factors in the expression of IL36G and IL36R in CC cells, (iii) to study the effect of IL-36γ in the expression of genes related to inflammation and ECM remodelling in CC cells and (iv) to determine the crosstalk between adipocytes and CC cells on the gene expression levels of IL36G and IL36R. This evidence concerns the gene IL1RL2 and obesity due to melanocortin 4 receptor deficiency.