IL36G and obesity due to melanocortin 4 receptor deficiency: In conclusion, the increased expression of IL36G in VAT of patients with obesity and CC underscores its importance in the tumour microenvironment and suggests that the inflammatory milieu and the remodelling of the ECM associated with obesity may drive the upregulation of IL-36 signalling pathways, which are known to contribute to tumorigenesis (Fig. 5).