Other limitations include the high cost for precise TKV measurements with CT and MRI, restriction to those aged between 15 and 80 years, limited applicability to ADPKD related to genes other than PKD1 or PKD2, and lack of adequate representation of non-white populations in the initial study cohort which could limit generalizability [5]. This evidence concerns the gene PKD2 and autosomal dominant polycystic kidney disease.