Points are assigned based on key variables: male sex (1 point), onset of hypertension before age 35 (2 points), a first urologic event (such as gross hematuria, cyst infection, or flank pain) before age 35 (2 points), and genetic variant type, with PKD2 variants receiving 0 points, non-truncating PKD1 variants 2 points, and truncating PKD1 variants 4 points (supplemental Figure S5). The gene discussed is PKD1; the disease is Hypertension.