Previous studies performed in mice found upregulated protein levels of enzymes involved in glucose uptake and cytoplasmic glycogen synthesis in skeletal muscle from mice with Pompe disease, including glycogenin (GYG1), glycogen synthase (GYS1), glucose transporter 4 (GLUT4), glycogen branching enzyme 1 (GBE1), and UDP‐glucose pyrophosphorylase (UGP2) suggesting a positive feedforward loop for cellular glycogen accumulation.13, 14. The gene discussed is GYG1; the disease is glycogen storage disease II.