GGH and neoplasm: To determine the effects of targeting GGH in a mouse subcutaneous tumor model, nude mice were subcutaneously injected with the stable A549 cell line where doxycycline (Dox) induces the expression of Tet-on-shCtrl or Tet-on-shGGH (Supplementary Figure S4L) and fed a Dox-containing diet (200 mg/kg).