Spearman's correlation analysis was conducted to examine the relationships between variables.In saliva samples, NLRP3, caspase-1, IL-1β, and IL-18 were the highest in the periodontitis group (<i>p</i> < 0.005), while IL-37 was highest in the healthy group (<i>p</i> < 0.005). This evidence concerns the gene NLRP3 and periodontitis.