MAN1B1 and Decreased liver function: Interestingly, similar clinical features (specifically intellectual disability, dysmorphism, behavioral abnormalities, seizures, and variable liver dysfunction) are also observed in MAN1B1-CDG associated with defective mannosyl-oligosaccharide alpha-1,2-mannosidase function (also known as ERManI) encoded by MAN1B1 (MIM: 604346).10