The associations between TI-CH and adverse outcomes, the increased odds of TI-CH with TET2-mutant CHIP, and the impact of TET2-mutant immune cells on the tumor microenvironment and cancer cell growth, support the role of TI-CH in tumor evolution and its potential utility in cancer diagnostics.18 Future studies should evaluate these findings in larger and more ethnically diverse cancer cohorts and further interrogate the functional impact of TI-CH on tumor progression. Here, C4B is linked to cancer.