TET2 and neoplasm: To evaluate whether TET2-mutant myeloid cells influence lung tumor cell growth, we cultured TRACERx patient-derived LUAD organoids36 with human TET2-mutant or wild-type myeloid cells from lungs of humanized mice engrafted with TET2-mutant or wild-type hematopoietic stem cells (Fig S28A–B).32 Co-cultures of tumor organoid cells with TET2-mutant myeloid cells resulted in larger and more numerous organoids compared to co-cultures with wild-type myeloid cells (Fig 4E–F).