TET2 and neoplasm: We induced lung tumors in Tet2-mutant CHIP mice by orthotopically transplanting KrasG12C 3LL LUAD cells, and analyzed blood, tumor and adjacent lung tissues (Fig S26A–C, S27A).31 Similar to our human results (Fig 1E), in mouse tumors Tet2-mutant cells were enriched within the myeloid and natural killer cell compartments relative to other cell populations (Fig S27B).