By assessing cardiac outcome in terms of fibrosis development, extent of hypertrophy, and multiple determinants of cardiac function, as well as by monitoring the proliferative behavior of isolated CF/CMF primary cell cultures, we ultimately wanted to clarify if the cGMP/cGKI signaling cascade in CMFs affects the adverse remodeling induced by chronic Ang II exposure. Here, PRKG1 is linked to cystic fibrosis.