Future studies should therefore consider other paracrine mediators such as fibroblast growth factor-2, ANP or BNP and their modulation upon pharmacological cGMP/cGKI stimulation as well as an in-depth analysis of the possible functions of this pathway in CF/CMF on Ca2+ handling mechanisms that ultimately may also affect neighboring CMs. The gene discussed is PRKG1; the disease is cystic fibrosis.