Such an MS67-caused reduction of H3K4me3 and H3K4me2 was obvious at the SS oncogenes and developmental genes (18, 19, 29) such as MNX1, forkhead box C1 (FOXC1), and frizzled class receptor 10 (FZD10) (Fig. 4F), as well as RP genes such as ribosomal protein L7 (RPL7) and ribosomal protein L35 (RPL35) (Fig. 4G), which were known to be critical targets of WDR5 in cancers (26, 40). The gene discussed is RPL35; the disease is cancer.