Such an interaction between the SWI/SNF and WDR5-containing complexes is lacking in the SS18::SSX-negative U2OS cells and thus appears to rely on the presence of SS18::SSX, which agrees with the quite selective killing effects of WDR5-degrading PROTAC on SS cells, when compared to non-SS sarcoma cells (fig. This evidence concerns the gene SMARCA1 and sarcoma.