In addition, WDR5 degradation by MS67 had little or very mild effects on the growth of a panel of tested non-SS sarcoma lines, such as Ewing sarcoma (A673 and RD-ES cells), rhabdomyosarcoma (A204, Rh4, and Rh10 cells), and osteosarcoma (U2OS cells) (fig. Here, WDR5 is linked to osteosarcoma.