MAPT and Alzheimer disease: Formation of membrane-less protein aggregates by LPS is also a prominent feature of neurodegenerative disorders (17–19), and pathological aggregation and toxicity of Tau in AD, fused in sarcoma (FUS) or TAR DNA-binding protein 43 (TDP-43) in ALS, and huntingtin in Huntington’s disease have been directly linked to their LPS (20–24).