Among the paired sample analyses, which involved 1404 samples in 23 cancers and 1404 paracancerous samples, GTF2E2 mRNA expression increased significantly in CHOL, COAD, HNSC, KIRC, KIRP, LUAD, LUSC, THCA, UCEC (all P < 0.001), BLCA (P = 0.014), ESCA (P = 0.018), PRAD (P = 0.010), READ (P = 0.007), and STAD (P = 0.020) (Fig 2C). This evidence concerns the gene GTF2E2 and cancer.