These pathways included cancer-related pathways, lipid and atherosclerosis pathways, the PI3K-Akt signaling pathway, proteoglycans in cancer, hepatitis B, human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, human papillomavirus infection, human immunodeficiency virus 1 infection, chemical carcinogenesis-receptor activation, the MAPK signaling pathway, salmonella infection, shigellosis, microRNAs in cancer, Alzheimer’s disease, and pathways related to neurodegeneration-multiple diseases. This evidence concerns the gene PIK3CA and Alzheimer disease.